SCHEMBL2452818

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2449304	0.89	CYP11B1 (0.38)	PIK3CAPIK3CDMTORCYP11B1CYP11B2
	SCHEMBL2450914	0.88	CYP11B1 (0.39)	PIK3CAPIK3CDMTORCYP11B1CYP11B2
	SCHEMBL2451435	0.81	PIK3CA (0.34)	PIK3CAPIK3CDMTORGLA
	SCHEMBL2451254	0.81	GRM5 (0.35)	PIK3CAMTORCYP11B2GLA
	SCHEMBL1074563	0.79	NOTUM (0.37)	CYP1A2GLAALDH1A1KDM4E
	SCHEMBL1074623	0.78	PIK3CA (0.41)	PIK3CAMAPTKDM4E
	SCHEMBL2451300	0.78	HTR3A (0.38)	PIK3CACYP11B1CYP11B2HTR3ACYP1A2
	SCHEMBL2450913	0.78	ALDH1A1 (0.38)	HTR3ACYP1A2NPC1MAPTRAB9A
	SCHEMBL2452981	0.78	OXTR (0.46)	—
	SCHEMBL1074256	0.76	GRM1 (0.43)	CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.