Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | ATM | Q13315 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10601850 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4EATMKMT2AMEN1 | |
| SCHEMBL10604885 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2KDM4EATMKMT2AMEN1 | |
| SCHEMBL10600924 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EATMKMT2AMEN1 | |
| SCHEMBL25481035 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EATMKMT2AMEN1 | |
| SCHEMBL22790774 | 0.81 | ALDH1A1 (0.68) | KMT2AMEN1RAB9ALMNAALDH1A1 | |
| SCHEMBL3194862 | 0.80 | ALDH1A1 (0.54) | KMT2AMEN1RAB9ALMNAALDH1A1 | |
| SCHEMBL11939427 | 0.80 | MAPK1 (0.58) | KDM4EKMT2AMEN1RAB9AMAPT | |
| SCHEMBL13632432 | 0.80 | CCR3 (0.69) | LMNASIGMAR1 | |
| SCHEMBL19170201 | 0.80 | CCR3 (0.69) | LMNASIGMAR1 | |
| SCHEMBL17830792 | 0.80 | SMN1; SMN2 (0.71) | SMN1; SMN2KDM4EATMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125804-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |