Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | ATM | Q13315 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10601850 | 0.85 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1ATMKDM4EHPGD | |
| SCHEMBL10604885 | 0.83 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1ATMKDM4EHPGD | |
| SCHEMBL24514293 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1ATMKDM4EHPGD | |
| SCHEMBL16122104 | 0.81 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1ATMHPGDMEN1 | |
| SCHEMBL12504054 | 0.81 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1ATMKDM4EHPGD | |
| SCHEMBL17830792 | 0.81 | SMN1; SMN2 (0.71) | SMN1; SMN2ALDH1A1ATMKDM4EHPGD | |
| SCHEMBL25967979 | 0.81 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1ATMKDM4EHPGD | |
| SCHEMBL13293323 | 0.79 | HRH3 (0.69) | SMN1; SMN2ALDH1A1ATMKDM4EMEN1 | |
| SCHEMBL3979002 | 0.79 | SIGMAR1 (0.63) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL25565610 | 0.78 | ALDH1A1 (0.66) | ALDH1A1KDM4EHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182349-B1 | BIS(ARYLPIPERAZINYL)SULFUR COMPOUNDS | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1989-04-26 | — | — | EP | disclosed |
| US-4692448-A | ANTIALLERGENS AND ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1987-09-08 | — | — | US | disclosed |
| EP-0182349-A1 | Bis(arylpiperazinyl)sulfur compounds | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1986-05-28 | — | — | EP | disclosed |