Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB1 | P15086 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24515749 | 1.00 | CPB1 (0.56) | CPB1KMT2AL3MBTL1CTSBCTSS | |
| SCHEMBL10137650 | 0.98 | CPB1 (0.56) | CPB1KMT2AL3MBTL1CTSBCTSS | |
| SCHEMBL12873056 | 0.98 | CPB1 (0.56) | CPB1KMT2AL3MBTL1CTSBCTSS | |
| SCHEMBL3563686 | 0.88 | KMT2A (0.56) | CPB1KMT2AL3MBTL1CTSBCTSS | |
| SCHEMBL2496331 | 0.88 | CACNA1B (0.51) | CPB1KMT2AL3MBTL1CTSBCTSS | |
| SCHEMBL4033681 | 0.85 | CPB1 (0.54) | CPB1KMT2AL3MBTL1CTSBCTSS | |
| SCHEMBL30441712 | 0.85 | KMT2A (0.53) | CPB1KMT2AL3MBTL1CTSBCTSS | |
| SCHEMBL12193476 | 0.84 | KMT2A (0.48) | CPB1KMT2AL3MBTL1CTSBCTSS | |
| SCHEMBL13712268 | 0.83 | CPB1 (0.78) | CPB1CTSBCTSSCTSKCASP3 | |
| SCHEMBL14161287 | 0.83 | CPB1 (0.78) | CPB1CTSBCTSSCTSKCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022122773-A1 | 4-(2-FLUORO-4-METHOXY-5-3-(((1-METHYLCYCLOBUTYL)METHYL)CARBAMOYL)BICYCLO[2.2.1]HEPTAN-2-YL)CARBAMOYL)PHENOXY)-1-METHYLCYCLOHEXANE-1-CARBOXYLIC ACID DERIVATIVES AND SIMILAR COMPOUNDS AS RXFP1 MODULATORS FOR THE TREATMENT OF HEART FAILURE | ASTRAZENECA AB (SE) | 2022-06-16 | — | — | WO | disclosed |