Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3506901 | 0.85 | SMN1; SMN2 (0.45) | EPHX2SIGMAR1HRH3HDAC1HDAC6 | |
| SCHEMBL2450084 | 0.81 | ALDH1A1 (0.39) | ATM | |
| SCHEMBL4127734 | 0.81 | EPHX2 (0.42) | EPHX2CYP2C9EPHX1SCN5ASIGMAR1 | |
| SCHEMBL22288737 | 0.78 | OPRM1 (0.36) | EPHX2SIGMAR1 | |
| SCHEMBL3222598 | 0.76 | SIGMAR1 (0.66) | EPHX2CYP2C9EPHX1SCN5ASIGMAR1 | |
| SCHEMBL2588053 | 0.76 | SIGMAR1 (0.66) | EPHX2CYP2C9EPHX1SCN5ASIGMAR1 | |
| SCHEMBL2455451 | 0.75 | CHRM3 (0.48) | SIGMAR1 | |
| SCHEMBL3213563 | 0.73 | SIGMAR1 (0.60) | EPHX2CYP2C9EPHX1SCN5ASIGMAR1 | |
| SCHEMBL3213557 | 0.73 | SIGMAR1 (0.60) | EPHX2CYP2C9EPHX1SCN5ASIGMAR1 | |
| SCHEMBL2449728 | 0.73 | SIGMAR1 (0.48) | EPHX2CYP2C9EPHX1SCN5ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364982-A1 | Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof | ONO Pharmaceutical Co., Ltd. (JP) | 2011-09-14 | — | — | EP | disclosed |