Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 2/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1317242 | 0.83 | MAPT (0.48) | SMN1; SMN2HRH3HRH4MAPTPDE10A | |
| SCHEMBL5791956 | 0.80 | CRHBP (0.55) | CRHBPCRHR2SMN1; SMN2HRH3HRH4 | |
| SCHEMBL6603334 | 0.76 | CRHBP (0.51) | CRHBPCRHR2SMN1; SMN2HRH3HRH4 | |
| SCHEMBL5790289 | 0.75 | CRHBP (0.50) | CRHBPCRHR2SMN1; SMN2HRH3HRH4 | |
| SCHEMBL21491405 | 0.73 | CRHBP (0.59) | CRHBPCRHR2SMN1; SMN2HRH3HRH4 | |
| SCHEMBL21491459 | 0.73 | CRHBP (0.59) | CRHBPCRHR2SMN1; SMN2HRH3HRH4 | |
| SCHEMBL21491406 | 0.73 | CRHBP (0.59) | CRHBPCRHR2SMN1; SMN2HRH3HRH4 | |
| SCHEMBL21516564 | 0.73 | CRHBP (0.59) | CRHBPCRHR2SMN1; SMN2HRH3HRH4 | |
| SCHEMBL29456355 | 0.73 | CRHBP (0.59) | CRHBPCRHR2SMN1; SMN2HRH3HRH4 | |
| SCHEMBL1318233 | 0.71 | CYP11B2 (0.45) | HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | disclosed |