Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD3 | Q15059 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13448836 | 0.91 | BRD3 (0.39) | BRD3DRD2SLC6A4HTR2AHTR7 | |
| SCHEMBL2451890 | 0.89 | BRD3 (0.36) | BRD3DRD2SLC6A4HTR2AHTR7 | |
| SCHEMBL2452129 | 0.86 | APP (0.39) | BRD3DRD2HTR2AHTR7NR1H2 | |
| SCHEMBL2449392 | 0.86 | BRD3 (0.38) | BRD3DRD2SLC6A4HTR2AHTR7 | |
| SCHEMBL13448818 | 0.82 | TGM2 (0.41) | — | |
| SCHEMBL2631835 | 0.78 | TDO2 (0.35) | BRD3DRD2SLC6A4HTR2AHTR7 | |
| SCHEMBL12329378 | 0.78 | CYP1A2 (0.35) | BRD3HTR2ANR1H2NR1H3TDO2 | |
| SCHEMBL12037508 | 0.77 | HTR1B (0.43) | BRD3DRD2HTR2AHTR7APP | |
| SCHEMBL2453968 | 0.77 | HTR1B (0.43) | BRD3DRD2HTR2AHTR7APP | |
| SCHEMBL2631836 | 0.77 | DRD2 (0.34) | BRD3DRD2SLC6A4HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920093-B2 | Dimeric IAP inhibitors | TetraLogic Birinapant UK Ltd. (GB) | 2018-03-20 | — | — | US | disclosed |
| US-20160355547-A1 | Dimeric IAP Inhibitors | TETRALOGIC BIRINAPANT UK LTD (GB) | 2016-12-08 | — | — | US | disclosed |
| US-20160052965-A1 | Dimeric IAP Inhibitors | TetraLogic Birinapant UK Ltd. (GB) | 2016-02-25 | — | — | US | disclosed |
| US-9187490-B2 | Dimeric IAP inhibitors | TetraLogic Birinapant UK Ltd. (GB) | 2015-11-17 | — | — | US | disclosed |
| US-20140329823-A1 | Dimeric IAP Inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2014-11-06 | — | — | US | disclosed |
| US-8822525-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2014-09-02 | — | — | US | disclosed |
| EP-1851200-B1 | DIMERIC IAP INHIBITORS | TETRALOGIC PHARM CORP (US) | 2014-01-15 | — | — | EP | disclosed |
| US-20130289042-A1 | DIMERIC IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORPORATION | 2013-10-31 | — | — | US | disclosed |
| US-8497297-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2013-07-30 | — | — | US | disclosed |
| US-20110301151-A1 | DIMERIC IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORPORATION | 2011-12-08 | — | — | US | disclosed |
| EP-2385038-A1 | Dimeric IAP inhibitors | Tetralogic Pharmaceuticals Corporation (US) | 2011-11-09 | — | — | EP | disclosed |
| US-8022230-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2011-09-20 | — | — | US | disclosed |
| US-20100075911-A1 | DIMERIC IAP INHIBITORS | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2010-03-25 | — | — | US | disclosed |
| US-7517906-B2 | Dimeric IAP inhibitors | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2009-04-14 | — | — | US | disclosed |
| US-20060194741-A1 | Dimeric IAP inhibitors | MEDIVIR AB (SE) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075911-A1 | DIMERIC IAP INHIBITORS | BIRC2, XIAP, BIRC5 | BRD3 1233/4885DRD2 4457/4885SLC6A4 3375/4885 |
| US-20110301151-A1 | DIMERIC IAP INHIBITORS | BIRC2, XIAP, BIRC5 | BRD3 1233/4885DRD2 4457/4885SLC6A4 3375/4885 |
| US-20140329823-A1 | Dimeric IAP Inhibitors | BIRC2, XIAP, BIRC5 | BRD3 1233/4885DRD2 4457/4885SLC6A4 3375/4885 |
| US-20160052965-A1 | Dimeric IAP Inhibitors | BIRC2, XIAP, BIRC5 | BRD3 1233/4885DRD2 4457/4885SLC6A4 3375/4885 |
| US-20060194741-A1 | Dimeric IAP inhibitors | BIRC2, BIRC3, BIRC5 | BRD3 926/4885DRD2 4570/4885SLC6A4 3577/4885 |
| US-20160355547-A1 | Dimeric IAP Inhibitors | BIRC2, XIAP, BIRC5 | BRD3 1233/4885DRD2 4457/4885SLC6A4 3375/4885 |
| US-20130289042-A1 | DIMERIC IAP INHIBITORS | BIRC2, XIAP, BIRC5 | BRD3 1233/4885DRD2 4457/4885SLC6A4 3375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.