Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 10/20 | 0.60 |
| ▸ | CTSK | P43235 | 9/20 | 0.60 |
| ▸ | CTSB | P07858 | 4/20 | 0.54 |
| ▸ | CTSL | P07711 | 3/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.46 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29052547 | 1.00 | CTSS (0.60) | CTSSCTSKCTSBCTSLSCN9A | |
| SCHEMBL29052278 | 0.89 | CTSS (0.66) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL24521571 | 0.89 | CTSS (0.66) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL24521561 | 0.89 | CTSS (0.51) | CTSSCTSKCTSBCTSLSCN9A | |
| SCHEMBL29052272 | 0.89 | CTSS (0.51) | CTSSCTSKCTSBCTSLSCN9A | |
| SCHEMBL7152899 | 0.83 | CTSS (0.67) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL12009170 | 0.83 | CTSS (0.48) | CTSSCTSKCTSBCTSLSCN9A | |
| SCHEMBL15244582 | 0.83 | CTSS (0.58) | CTSSCTSKCTSBCTSLSCN9A | |
| SCHEMBL12009168 | 0.82 | CTSS (0.53) | CTSSCTSK | |
| SCHEMBL17133714 | 0.82 | CTSK (0.48) | CTSSCTSKCTSBCTSLSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116583497-A | N-benzyl-alpha-aminoamides as late promoting complex/loop (APC/C) inhibitors | 科学研究高级委员会(CSIC) | 2023-08-11 | — | — | CN | disclosed |
| WO-2022129397-A1 | N-BENZYL-ALPHA-AMINOAMIDES AS ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC/C) INHIBITORS | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2022-06-23 | — | — | WO | disclosed |
| EP-4015501-A1 | N-BENZYL-ALPHA-AMINOAMIDES AS ANAPHASE-PROMOTING COMPLEX/CYCLOSOME (APC/C) INHIBITORS | Consejo Superior de Investigaciones Científicas (CSIC) (ES) | 2022-06-22 | — | — | EP | disclosed |