Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19616555 | 0.81 | HDAC6 (0.72) | HDAC6KDM4EALDH1A1HPGDHTT | |
| SCHEMBL9093698 | 0.80 | HDAC6 (0.67) | HDAC6KDM4EALDH1A1HPGDHTT | |
| SCHEMBL19616809 | 0.79 | HDAC6 (1.00) | HDAC6KDM4EALDH1A1HPGDHTT | |
| SCHEMBL28048000 | 0.77 | PDGFRB (0.61) | HDAC6KDM4EALDH1A1HPGDHTT | |
| SCHEMBL28014135 | 0.76 | FLT1 (0.65) | HDAC6KDM4EALDH1A1HPGDHTT | |
| SCHEMBL5018962 | 0.74 | HDAC6 (0.64) | HDAC6KDM4EALDH1A1HPGDHTT | |
| SCHEMBL846145 | 0.72 | KDR (0.72) | HDAC6KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL19631296 | 0.71 | KDM4E (0.69) | HDAC6KDM4EALDH1A1HPGDHTT | |
| SCHEMBL12895711 | 0.71 | RAB9A (0.59) | HDAC6KDM4EALDH1A1HPGDHTT | |
| SCHEMBL19631297 | 0.71 | HDAC6 (0.69) | HDAC6KDM4EALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458444-B1 | HISTONE DEACETYLASE 6 INHIBITORS AND USE THEREOF | UNIV TAIPEI MEDICAL (TW) | 2022-06-22 | — | — | EP | disclosed |