SCHEMBL24523748

SCHEMBL24523748

N#Cc1cc2c(cc1-c1ccc(-c3ccccc3)cc1)c1cccc3c4cc(-c5ccc(-c6ccccc6)cc5)c(C#N)cc4n2c13

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOA P21397 4/20 0.39
MAOB P27338 2/20 0.39
CYP19A1 P11511 2/20 0.37
MCL1 Q07820 2/20 0.36
CNR1 P21554 1/20 0.36
ALDH1A1 P00352 4/20 0.35
KDM4E B2RXH2 3/20 0.35
GAA P10253 2/20 0.35
GLA P06280 1/20 0.35
NPSR1 Q6W5P4 2/20 0.35
HPGD P15428 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
GALR3 O60755 1/20 0.35
ESR2 Q92731 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24523907 0.97 MAOA (0.40) MAOAMAOBCYP19A1CNR1ALDH1A1
SCHEMBL24523757 0.93 MAOA (0.38) MAOAMAOBCYP19A1MCL1ALDH1A1
SCHEMBL24523768 0.90 MAOA (0.38) MAOAMAOBCYP19A1MCL1ALDH1A1
SCHEMBL24524238 0.89 MAOA (0.37) MAOAMAOBCYP19A1MCL1CNR1
SCHEMBL24523756 0.85 PIM1 (0.40) MCL1
SCHEMBL24523761 0.83 SLC22A12 (0.37) MAOAMAOBCYP19A1MCL1ALDH1A1
SCHEMBL24523763 0.80 MCL1 (0.43) MCL1
SCHEMBL24523772 0.79 CA1 (0.36) MAOAMAOBMCL1ALDH1A1KDM4E
SCHEMBL24524245 0.79 TRPA1 (0.34) MAOA
SCHEMBL24524244 0.77 MAP4K1 (0.37) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022129116-A1 INDOLO[3.2.1-JK]CARBAZOLE-6-CARBONITRILE DERIVATIVES AS BLUE FLUORESCENT EMITTERS FOR USE IN OLEDS MERCK PATENT GMBH (DE) 2022-06-23 WO disclosed