SCHEMBL2452835

SCHEMBL2452835

CC(CCc1ccccn1)(CCc1ccccn1)C(=O)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.57
SMN1; SMN2 Q16637 3/20 0.54
CYP2C19 P33261 1/20 0.54
RAB9A P51151 2/20 0.46
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
MAPT P10636 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
LMNA P02545 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
PTPRA P18433 1/20 0.43
HRH3 Q9Y5N1 1/20 0.42
HRH1 P35367 1/20 0.42
GAA P10253 1/20 0.42
NPC1 O15118 1/20 0.42
TAAR1 Q96RJ0 1/20 0.41
ALOX15 P16050 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30925300 1.00 CYP1A2 (0.57) CYP1A2SMN1; SMN2CYP2C19RAB9AALDH1A1
SCHEMBL11074830 0.87 CYP1A2 (0.56) CYP1A2SMN1; SMN2CYP2C19RAB9AALDH1A1
SCHEMBL3239462 0.81 CYP1A2 (0.52) CYP1A2SMN1; SMN2CYP2C19RAB9AALDH1A1
SCHEMBL10759826 0.80 CYP1A2 (0.49) CYP1A2SMN1; SMN2CYP2C19RAB9AALDH1A1
SCHEMBL8503990 0.80 CYP1A2 (0.70) CYP1A2SMN1; SMN2CYP2C19RAB9AALDH1A1
SCHEMBL6532240 0.77 CYP1A2 (0.58) CYP1A2SMN1; SMN2CYP2C19RAB9AALDH1A1
SCHEMBL7206606 0.76 CYP1A2 (0.56) CYP1A2SMN1; SMN2CYP2C19RAB9ALMNA
SCHEMBL116939 0.75 CYP1A2 (0.58) CYP1A2SMN1; SMN2CYP2C19RAB9AALDH1A1
SCHEMBL30195799 0.75 CYP1A2 (0.58) CYP1A2SMN1; SMN2CYP2C19RAB9AALDH1A1
SCHEMBL27461429 0.74 CYP1A2 (0.55) CYP1A2SMN1; SMN2CYP2C19RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9133039-B2 Kinase inhibitor compounds UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-09-15 US claimed
US-8367078-B2 Kinase inhibitor compounds UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2013-02-05 US claimed
WO-2011109217-A2 METHODS OF TREATING OR PREVENTING RNA POLYMERASE DEPENDENT VIRAL DISORDERS BY ADMINISTRATION OF JAK2 KINASE INHIBITORS IMMUNODIAGNOSTICS, INC. (US) 2011-09-09 WO claimed
US-20260097028-A1 Methods of Treating Myeloproliferative Neoplasms KARTOS THERAPEUTICS INC (US) 2026-04-09 US disclosed
US-20250387383-A1 METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS KARTOS THERAPEUTICS, INC. (US) 2025-12-25 US disclosed
US-12268681-B2 Methods of treating myeloproliferative neoplasms KARTOS THERAPEUTICS, INC. (US) 2025-04-08 US disclosed
WO-2024124240-A1 METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS KARTOS THERAPEUTICS (US) 2024-06-13 WO disclosed
EP-3803402-B1 ANTI-CANCER TREATMENT OF PRESELECTED SUBJECTS AND SCREENING METHODS TO IDENTIFY SUSCEPTIBLE SUBJECTS TUDAG TU DRESDEN AG (DE) 2023-04-26 EP disclosed
US-20220054472-A1 Methods of Treating Myeloproliferative Neoplasms KARTOS THERAPEUTICS INC. 2022-02-24 US disclosed
EP-3578981-B1 ANTI-CANCER TREATMENT OF PRESELECTED SUBJECTS AND SCREENING METHODS TO IDENTIFY SUSCEPTIBLE SUBJECTS TUDAG TU DRESDEN AG (DE) 2021-10-27 EP disclosed
US-20210251944-A1 METHODS FOR TREATING A CANCER RESISTANT TO AT LEAST ONE TYROSINE KINASE INHIBITOR DEL MAR PHARMACEUTICALS (BC) LTD. (CA) 2021-08-19 US disclosed
US-9133039-B2 Kinase inhibitor compounds UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-09-15 US disclosed
US-20150182490-A1 METHODS FOR TREATING TYROSINE-KINASE-INHIBITOR-RESISTANT MALIGNANCIES IN PATIENTS WITH GENETIC POLYMORPHISMS OR AHI1 DYSREGULATIONS OR MUTATIONS EMPLOYING DIANHYDROGALACTITOL, DIACETYLDIANHYDROGALACTITOL, DIBROMODULCITOL, OR ANALOGS OR DERIVATIVES THEREOF DEL MAR PHARMACEUTICALS (BC) LTD. (CA) 2015-07-02 US disclosed
EP-2872161-A2 METHODS FOR TREATING TYROSINE-KINASE-INHIBITOR-RESISTANT MALIGNANCIES IN PATIENTS WITH GENETIC POLYMORPHISMS OR AHI1 DYSREGULATIONS OR MUTATIONS EMPLOYING DIANHYDROGALACTITOL, DIACETYLDIANHYDROGALACTITOL, DIBROMODULCITOL, OR ANALOGS OR DERIVATIVES THEREOF Del Mar Pharmaceuticals (CA) 2015-05-20 EP disclosed
US-20140193518-A1 KINASE INHIBITOR COMPOUNDS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2014-07-10 US disclosed
WO-2014004376-A2 METHODS FOR TREATING TYROSINE-KINASE-INHIBITOR-RESISTANT MALIGNANCIES IN PATIENTS WITH GENETIC POLYMORPHISMS OR AHI1 DYSREGULATIONS OR MUTATIONS EMPLOYING DIANHYDROGALACTITOL, DIACETYLDIANHYDROGALACTITOL, DIBROMODULCITOL, OR ANALOGS OR DERIVATIVES THEREOF DEL MAR PHARMACEUTICALS (CA) 2014-01-03 WO disclosed
US-8367078-B2 Kinase inhibitor compounds UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2013-02-05 US disclosed
WO-2011109217-A2 METHODS OF TREATING OR PREVENTING RNA POLYMERASE DEPENDENT VIRAL DISORDERS BY ADMINISTRATION OF JAK2 KINASE INHIBITORS IMMUNODIAGNOSTICS, INC. (US) 2011-09-09 WO disclosed
US-20100278933-A1 KINASE INHIBITOR COMPOUNDS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC (US) 2010-11-04 US disclosed
WO-2008153900-A1 KINASE INHIBITOR COMPOUNDS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) 2008-12-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100278933-A1 KINASE INHIBITOR COMPOUNDS MAP3K1, MAP3K2, MAP3K6 CYP1A2 2306/4885SMN1; SMN2 3924/4885CYP2C19 2607/4885
US-20250387383-A1 METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS JAK2, JAK1, MPL CYP1A2 2351/4885SMN1; SMN2 605/4885CYP2C19 2419/4885
US-20220054472-A1 Methods of Treating Myeloproliferative Neoplasms JAK2, JAK1, PDPK1 CYP1A2 1459/4885SMN1; SMN2 1510/4885CYP2C19 1775/4885
US-20140193518-A1 KINASE INHIBITOR COMPOUNDS MAP3K1, MAP3K2, MAP3K6 CYP1A2 2306/4885SMN1; SMN2 3924/4885CYP2C19 2607/4885
US-20150182490-A1 METHODS FOR TREATING TYROSINE-KINASE-INHIBITOR-RESISTANT MALIGNANCIES IN PATIENTS WITH GENETIC POLYMORPHISMS OR AHI1 DYSREGULATIONS OR MUTATIONS EMPLOYING DIANHYDROGALACTITOL, DIACETYLDIANHYDROGALACTITOL, DIBROMODULCITOL, OR ANALOGS OR DERIVATIVES THEREOF WHR1, AIPL1, TDP1 CYP1A2 4534/4885SMN1; SMN2 3505/4885CYP2C19 4619/4885
US-12268681-B2 Methods of treating myeloproliferative neoplasms JAK2, JAK1, PDPK1 CYP1A2 1459/4885SMN1; SMN2 1510/4885CYP2C19 1775/4885
US-20210251944-A1 METHODS FOR TREATING A CANCER RESISTANT TO AT LEAST ONE TYROSINE KINASE INHIBITOR DCLRE1B, AIPL1, WHR1 CYP1A2 4656/4885SMN1; SMN2 3557/4885CYP2C19 4731/4885
US-20260097028-A1 Methods of Treating Myeloproliferative Neoplasms JAK2, TP53, CDKN1A CYP1A2 3549/4885SMN1; SMN2 1272/4885CYP2C19 3916/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.