Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.35 |
| ▸ | GLA | P06280 | 4/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2456050 | 0.79 | ALDH1A1 (0.39) | ALDH1A1MAPTL3MBTL1KDM4EKMT2A | |
| SCHEMBL18816696 | 0.61 | ALDH1A1 (0.39) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL7062638 | 0.59 | BRD4 (0.37) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL15977332 | 0.58 | BRD4 (0.40) | ALDH1A1MAPTL3MBTL1KDM4EGLA | |
| Urea SCHEMBL4974754 | 0.57 | RAB9A (0.43) | ALDH1A1MAPTL3MBTL1KDM4EKMT2A | |
| SCHEMBL18991369 | 0.57 | BRD4 (0.40) | ALDH1A1MAPTL3MBTL1KDM4EGLA | |
| SCHEMBL7062104 | 0.56 | ALDH1A1 (0.35) | ALDH1A1MAPTL3MBTL1KDM4EKMT2A | |
| SCHEMBL1554818 | 0.56 | POLB (0.50) | ALDH1A1MAPTL3MBTL1KDM4EKMT2A | |
| SCHEMBL7815170 | 0.56 | ALDH1A1 (0.59) | ALDH1A1MAPTL3MBTL1KDM4EKMT2A | |
| SCHEMBL11565945 | 0.56 | ALDH1A1 (0.51) | ALDH1A1MAPTL3MBTL1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663193-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DIABETES | Applied Research Systems ARS Holding N.V. (AN) | 2006-06-07 | — | — | EP | claimed |
| WO-2005025558-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DIABETES | APPLIED RESERACH SYSTEMS ARS HOLDING N.V. (AN) | 2005-03-24 | — | — | WO | claimed |
| US-8012995-B1 | Pharmaceutically active sulfonamide derivatives | MERCK SERONO SA (CH) | 2011-09-06 | — | — | US | disclosed |
| US-7544700-B2 | Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein JunKinases | LABORATOIRES SERONO SA (CH) | 2009-06-09 | — | — | US | disclosed |