Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2451330 | 0.91 | LMNA (0.41) | LMNAPOLBSMN1; SMN2L3MBTL1HRH2 | |
| SCHEMBL2421225 | 0.81 | GPR119 (0.56) | GPR119NAMPT | |
| SCHEMBL26124220 | 0.80 | PDE4B (0.43) | LMNAPOLBSMN1; SMN2L3MBTL1GPR119 | |
| SCHEMBL2447286 | 0.79 | POLB (0.44) | LMNAPOLBSMN1; SMN2L3MBTL1HRH2 | |
| SCHEMBL2445428 | 0.78 | CHRM4 (0.51) | LMNAPOLBSMN1; SMN2L3MBTL1HRH2 | |
| SCHEMBL2454702 | 0.78 | CHRM4 (0.46) | LMNAPOLBSMN1; SMN2L3MBTL1HRH2 | |
| SCHEMBL8306843 | 0.76 | HRH2 (0.46) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL2453725 | 0.76 | LMNA (0.44) | LMNAPOLBSMN1; SMN2HRH2HRH1 | |
| SCHEMBL2447700 | 0.76 | POLB (0.46) | LMNAPOLBSMN1; SMN2L3MBTL1HRH2 | |
| SCHEMBL2450467 | 0.76 | POLB (0.49) | LMNAPOLBSMN1; SMN2L3MBTL1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550252-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | Theravance, Inc. (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119461-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-09-29 | — | — | WO | disclosed |