Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 3/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922008 | 0.83 | CHRM4 (0.59) | LMNAHRH3POLBSMN1; SMN2CHRM4 | |
| SCHEMBL30376364 | 0.81 | LMNA (0.49) | HRH2HRH1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL9172873 | 0.80 | CHRM4 (0.47) | HRH2HRH1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL21996849 | 0.79 | NAMPT (0.50) | HRH2HRH1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL4969308 | 0.79 | LMNA (0.46) | HRH2HRH1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL6950631 | 0.78 | GPR119 (0.53) | LMNA | |
| SCHEMBL9174231 | 0.78 | HRH1 (0.51) | HRH2HRH1LMNAHRH3POLB | |
| SCHEMBL4562521 | 0.77 | KDM4E (0.45) | LMNAHRH3SMN1; SMN2KCNH2 | |
| SCHEMBL15950973 | 0.77 | CHRM2 (0.60) | LMNASMN1; SMN2CHRM4NOS2CHRM2 | |
| SCHEMBL2451330 | 0.76 | LMNA (0.41) | HRH2HRH1LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966462-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998035959-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS OXIDO-SQUALENE CYCLASE INHIBITORS | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |