Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 6/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17681745 | 0.89 | UCHL1 (0.38) | UCHL1NR1H2NR1H3GHSRDRD1 | |
| SCHEMBL22180581 | 0.89 | UCHL1 (0.38) | UCHL1NR1H2NR1H3GHSRDRD1 | |
| SCHEMBL30878494 | 0.89 | UCHL1 (0.40) | UCHL1NR1H2GHSRDRD1CYP3A4 | |
| SCHEMBL24528950 | 0.88 | ALDH1A1 (0.47) | UCHL1GHSRDRD1CYP3A4HTR1A | |
| SCHEMBL18794436 | 0.86 | UCHL1 (0.41) | UCHL1NR1H2NR1H3GHSRDRD1 | |
| SCHEMBL17681686 | 0.86 | UCHL1 (0.41) | UCHL1NR1H2NR1H3GHSRDRD1 | |
| SCHEMBL24528905 | 0.86 | UCHL1 (0.38) | UCHL1NR1H2NR1H3GHSRDRD1 | |
| SCHEMBL24529019 | 0.86 | GHSR (0.36) | UCHL1GHSRDRD1CYP3A4HTR1A | |
| SCHEMBL33532199 | 0.85 | UCHL1 (0.41) | UCHL1NR1H2GHSRDRD1CYP3A4 | |
| SCHEMBL30878563 | 0.85 | UCHL1 (0.43) | UCHL1NR1H2NR1H3GHSRDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4263511-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | Amphista Therapeutics Ltd (GB) | 2023-10-25 | — | — | EP | disclosed |
| CN-116897150-A | Novel bifunctional molecules for protein-targeted degradation | 安菲斯塔治疗有限公司 | 2023-10-17 | — | — | CN | disclosed |
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |