Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.40 |
| ▸ | CD63 | P08962 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529207 | 0.87 | HDAC6 (0.37) | SYKCD63HDAC6CFDEPHB4 | |
| SCHEMBL24529150 | 0.84 | HTR7 (0.45) | SYKCD63HDAC6HTR7HTR1A | |
| SCHEMBL24529142 | 0.81 | HCRTR2 (0.46) | SYKCD63EPHB4AURKA | |
| SCHEMBL27181434 | 0.78 | SYK (0.39) | SYKCD63HDAC6AURKA | |
| SCHEMBL24529318 | 0.78 | SYK (0.39) | SYKCD63HDAC6AURKA | |
| SCHEMBL24529535 | 0.78 | DYRK1A (0.47) | — | |
| SCHEMBL2897650 | 0.77 | SYK (0.73) | SYKCD63 | |
| SCHEMBL24529311 | 0.72 | HCRTR2 (0.45) | SYKCD63EPHB4AURKA | |
| SCHEMBL24386985 | 0.72 | EPHB4 (0.41) | SYKCD63EPHB4AURKA | |
| SCHEMBL27179410 | 0.72 | HCRTR2 (0.54) | SYKHDAC6EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |