Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | CFD | P00746 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | CD63 | P08962 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529319 | 0.87 | SYK (0.40) | HDAC6HTR1ACFDEPHB4CD63 | |
| SCHEMBL29723821 | 0.81 | HCRTR2 (0.35) | HDAC6JAK2JAK1PDE4BPDE4D | |
| SCHEMBL24529205 | 0.81 | HCRTR2 (0.35) | HDAC6JAK2JAK1PDE4BPDE4D | |
| SCHEMBL27180720 | 0.81 | HCRTR2 (0.35) | HDAC6JAK2JAK1PDE4BPDE4D | |
| SCHEMBL29723692 | 0.76 | HCRTR2 (0.37) | HDAC6CFDPDE4D | |
| SCHEMBL24529350 | 0.76 | TLR9 (0.37) | HDAC6CFDJAK2JAK1PDE4D | |
| SCHEMBL24529535 | 0.74 | DYRK1A (0.47) | NMT1PRMT6 | |
| SCHEMBL24529142 | 0.73 | HCRTR2 (0.46) | EPHB4CD63SYK | |
| SCHEMBL24529380 | 0.73 | HCRTR2 (0.42) | HDAC6CFDJAK2JAK1PDE4D | |
| SCHEMBL27180128 | 0.72 | HCRTR2 (0.48) | HDAC6CFDPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |