Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | PGK1 | P00558 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12467200 | 0.81 | PGK1 (0.40) | PGK1GSK3BMAP4K2ALDH1A1KMT2A | |
| SCHEMBL24386891 | 0.81 | HTR2A (0.45) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL30716907 | 0.78 | NPC1 (0.38) | PGK1GSK3BMAP4K2ALDH1A1KMT2A | |
| SCHEMBL6607812 | 0.78 | NPC1 (0.38) | PGK1GSK3BMAP4K2ALDH1A1KMT2A | |
| SCHEMBL15142051 | 0.71 | GAA (0.42) | ALDH1A1GAAKDM4ETDP1LMNA | |
| SCHEMBL15142703 | 0.71 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2LMNAMAPTTP53 | |
| SCHEMBL24529330 | 0.70 | ALDH1A1 (0.36) | HTR1AHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL15591654 | 0.70 | DPP4 (0.47) | ALDH1A1KMT2AGAAKDM4EMEN1 | |
| SCHEMBL20225783 | 0.69 | NPC1 (0.43) | PGK1GSK3BMAP4K2ALDH1A1KMT2A | |
| SCHEMBL16200298 | 0.69 | ALDH1A1 (0.47) | HTR1AHTR1DHTR1BHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |