Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.78 |
| ▸ | RAB9A | P51151 | 8/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.78 |
| ▸ | HPGD | P15428 | 4/20 | 0.78 |
| ▸ | MAPT | P10636 | 9/20 | 0.77 |
| ▸ | HTT | P42858 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.58 |
| ▸ | SLC2A2 | P11168 | 4/20 | 0.58 |
| ▸ | SLC2A3 | P11169 | 4/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24533636 | 0.88 | NPC1 (0.79) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL24533662 | 0.87 | MAPT (1.00) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL24533664 | 0.86 | RAB9A (0.76) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL29618261 | 0.79 | MAPT (1.00) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL21568696 | 0.79 | MAPT (1.00) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7658416 | 0.78 | MAPT (0.80) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL2628836 | 0.74 | SLC2A1 (0.77) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL2628843 | 0.74 | MAPT (0.80) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6706131 | 0.73 | MAPT (0.71) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL13390339 | 0.73 | MAPT (0.67) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133237-A2 | METHODS OF TREATING NEURODEGENERATIVE DISORDERS AND STAT3-LINKED CANCERS USING SUPPRESSORS OF ELECTRON LEAK | CORNELL UNIVERSITY (US) | 2022-06-23 | — | — | WO | disclosed |