Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 5/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2455141 | 0.88 | KDM4A (0.39) | MBOAT4KDM4AKDM5AKDM5BPDE2A | |
| SCHEMBL2464506 | 0.88 | MBOAT4 (0.40) | MBOAT4KDM4AKDM5AKDM5BADORA2B | |
| SCHEMBL2465551 | 0.88 | MBOAT4 (0.40) | MBOAT4KDM4AKDM5AKDM5BADORA2B | |
| SCHEMBL2466816 | 0.87 | ALKBH3 (0.39) | MAOB | |
| SCHEMBL2456758 | 0.82 | KDM4A (0.38) | MBOAT4KDM4AKDM5AKDM5BADORA2B | |
| SCHEMBL2456756 | 0.81 | PDE2A (0.46) | MBOAT4KDM4AKDM5AKDM5BPDE2A | |
| SCHEMBL2456189 | 0.77 | NR3C2 (0.37) | MBOAT4ADORA2BPDE2AP2RX7AR | |
| SCHEMBL2541935 | 0.77 | MBOAT4 (0.37) | MBOAT4ADORA2BPDE2AP2RX7AR | |
| SCHEMBL2457055 | 0.71 | AR (0.35) | MBOAT4ADORA2BPDE2AP2RX7AR | |
| SCHEMBL12324705 | 0.71 | KDM4A (0.36) | KDM4AKDM5AKDM5BMAOBP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |