Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 9/20 | 0.37 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465551 | 0.90 | MBOAT4 (0.40) | MBOAT4PDE2AADORA2B | |
| SCHEMBL2456189 | 0.88 | NR3C2 (0.37) | MBOAT4APLNRARPDE2ANR3C2 | |
| SCHEMBL2461078 | 0.81 | ENPP1 (0.42) | — | |
| SCHEMBL2457055 | 0.78 | AR (0.35) | MBOAT4ARPDE2ANR3C2ADORA2B | |
| SCHEMBL2455141 | 0.77 | KDM4A (0.39) | MBOAT4PDE2ASCDP2RX7 | |
| SCHEMBL2453480 | 0.77 | MBOAT4 (0.39) | MBOAT4ARPDE2AADORA2BP2RX7 | |
| SCHEMBL2457053 | 0.77 | PDE2A (0.45) | MBOAT4ARPDE2AP2RX7 | |
| SCHEMBL2464506 | 0.73 | MBOAT4 (0.40) | MBOAT4PDE2AADORA2BP2RX7 | |
| SCHEMBL12324393 | 0.71 | NR3C2 (0.36) | MBOAT4APLNRARNR3C2ADORA2B | |
| SCHEMBL2455233 | 0.70 | DAO (0.38) | MBOAT4P2RX7LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |