Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.60 |
| ▸ | PDE4A | P27815 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.60 |
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | GALR3 | O60755 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29424274 | 1.00 | PDE3A (0.60) | PDE3AHPGDKDM4EPDE3BPDE4A | |
| SCHEMBL7344339 | 0.91 | PDE3A (0.60) | PDE3AHPGDKDM4EPDE3BPDE4A | |
| SCHEMBL20675641 | 0.79 | ADORA2A (0.52) | HPGDKDM4EALDH1A1GALR3GAA | |
| SCHEMBL20675029 | 0.79 | ADORA2A (0.50) | PDE3AHPGDKDM4EPDE3BPDE4A | |
| SCHEMBL20675734 | 0.78 | ADORA2A (0.49) | PDE3AHPGDKDM4EPDE3BPDE4A | |
| SCHEMBL29077106 | 0.78 | NPC1 (0.59) | HPGDKDM4EBLMLMNATSHR | |
| SCHEMBL20675740 | 0.78 | ADORA2A (0.51) | PDE3AHPGDKDM4EPDE3BPDE4A | |
| SCHEMBL10912708 | 0.77 | PDE3A (0.72) | PDE3AHPGDKDM4EPDE3BPDE4A | |
| SCHEMBL1150800 | 0.77 | NPC1 (0.54) | KDM4ETSHRCYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL10981195 | 0.76 | KDM4E (0.62) | PDE3AHPGDKDM4EPDE3BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1176960-B1 | SYNERGISTIC COMBINATION COMPRISING ROFLUMILAST AND A PDE-3 INHIBITOR | ALTANA PHARMA AG (DE) | 2004-09-29 | — | — | EP | claimed |
| US-5141931-A | 5-Quinolinylpyridinones, cardiotonic compositions and methods | STERLING WINTHROP INC. (US) | 1992-08-25 | — | — | US | claimed |
| US-20110224128-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY | WHALEN ANNE | 2011-09-15 | — | — | US | disclosed |
| EP-1176960-B1 | SYNERGISTIC COMBINATION COMPRISING ROFLUMILAST AND A PDE-3 INHIBITOR | ALTANA PHARMA AG (DE) | 2004-09-29 | — | — | EP | disclosed |
| US-5141931-A | 5-Quinolinylpyridinones, cardiotonic compositions and methods | STERLING WINTHROP INC. (US) | 1992-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224128-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY | PYGM, TNNC1, MYOF | PDE3A 49/4885HPGD 1435/4885KDM4E 2360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.