Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | GRK2 | P25098 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13118303 | 0.84 | NPC1 (0.60) | CYP1A2CYP2C19CYP2D6NPC1RAB9A | |
| SCHEMBL10263733 | 0.80 | WDR5 (0.48) | ROCK2CHRM3SMYD3 | |
| SCHEMBL1568385 | 0.78 | ROCK2 (0.62) | CYP1A2CYP2C19CYP2D6NPC1RAB9A | |
| SCHEMBL24538335 | 0.78 | NAMPT (0.48) | ROCK2NAMPTCHRM3LMNASMN1; SMN2 | |
| SCHEMBL14044800 | 0.77 | HDAC2 (0.69) | NPC1RAB9ASMN1; SMN2GAAEPHX2 | |
| SCHEMBL3033967 | 0.76 | ROCK2 (0.53) | CYP1A2CYP2C19CYP2D6NPC1RAB9A | |
| SCHEMBL12529799 | 0.75 | RAB9A (0.56) | CYP1A2CYP2C19CYP2D6NPC1RAB9A | |
| SCHEMBL3454745 | 0.75 | ROCK2 (0.52) | CYP1A2CYP2C19CYP2D6NPC1RAB9A | |
| SCHEMBL12228148 | 0.75 | GAA (0.61) | CYP2D6ROCK2NAMPTTSHRLMNA | |
| SCHEMBL9691071 | 0.75 | KAT6A (0.55) | CYP1A2CYP2C19NPC1RAB9ACHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022128851-A1 | DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-06-23 | — | — | WO | disclosed |