Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12306050 | 0.92 | MAPT (0.60) | MAPTKMT2AALDH1A1RAB9AMCL1 | |
| Trifluoroacetic Acid SCHEMBL5333651 | 0.89 | MAPT (0.46) | MAPTKMT2AALDH1A1RAB9AMCL1 | |
| Trifluoroacetic Acid SCHEMBL29803762 | 0.89 | RAB9A (0.56) | MAPTKMT2AALDH1A1RAB9AMCL1 | |
| Trifluoroacetic Acid SCHEMBL5333653 | 0.86 | MAPT (0.46) | MAPTKMT2AALDH1A1RAB9AHSD17B10 | |
| SCHEMBL27694104 | 0.83 | MAPT (0.57) | MAPTKMT2AALDH1A1RAB9AMCL1 | |
| SCHEMBL27694107 | 0.83 | MAPT (0.57) | MAPTKMT2AALDH1A1RAB9AMCL1 | |
| SCHEMBL2453870 | 0.81 | RAB9A (0.54) | MAPTKMT2AALDH1A1RAB9AMCL1 | |
| SCHEMBL22495337 | 0.81 | MAPT (0.79) | MAPTKMT2AALDH1A1RAB9AMCL1 | |
| SCHEMBL24891825 | 0.80 | RAB9A (0.64) | MAPTKMT2AALDH1A1RAB9AMCL1 | |
| SCHEMBL1663115 | 0.79 | ALDH1A1 (0.66) | MAPTKMT2AALDH1A1RAB9AMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799663-B1 | Modulators of HCV replication | ANGELETTI P IST RICHERCHE BIO (IT) | 2012-08-01 | — | — | EP | disclosed |
| US-8012982-B2 | Modulators of HCV replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-09-06 | — | — | US | disclosed |
| US-20090069344-A1 | Modulators of hcv replication | ISTITUTO DI RICERCHE BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069344-A1 | Modulators of hcv replication | EIF2AK2, IRF3, IFNAR1 | MAPT 4662/4885KMT2A 3871/4885ALDH1A1 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.