Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24540605 | 0.87 | TRPM8 (0.47) | TRPM8TRPV1KDM4EALDH1A1HPGD | |
| SCHEMBL24540647 | 0.85 | TRPM8 (0.46) | TRPM8TRPV1ALDH1A1HPGDEPHX1 | |
| SCHEMBL24540789 | 0.83 | TRPM8 (0.46) | TRPM8TRPV1KDM4EALDH1A1MAPT | |
| SCHEMBL24540645 | 0.81 | TRPM8 (0.47) | TRPM8TRPV1KDM4EGAAEPHX1 | |
| SCHEMBL24540846 | 0.79 | TRPM8 (0.58) | TRPM8TRPV1MAPTHTTMEN1 | |
| SCHEMBL24540501 | 0.79 | TRPM8 (0.47) | TRPM8TRPV1ALDH1A1HPGDEPHX1 | |
| SCHEMBL2628610 | 0.78 | TRPM8 (0.50) | TRPM8TRPV1ALDH1A1GAAEPHX1 | |
| SCHEMBL19058455 | 0.78 | TRPM8 (0.50) | TRPM8TRPV1ALDH1A1GAAEPHX1 | |
| SCHEMBL24540511 | 0.78 | TRPM8 (0.50) | TRPM8TRPV1ALDH1A1GAAEPHX1 | |
| SCHEMBL891394 | 0.78 | TRPM8 (0.50) | TRPM8TRPV1ALDH1A1GAAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133027-A1 | SUBSTITUTED CYCLOHEXANECARBOXAMIDES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-06-23 | — | — | WO | disclosed |