Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24540511 | 1.00 | TRPM8 (0.50) | TRPM8EPHX1TRPV1KCNA5ALDH1A1 | |
| SCHEMBL19058455 | 1.00 | TRPM8 (0.50) | TRPM8EPHX1TRPV1KCNA5ALDH1A1 | |
| SCHEMBL2628610 | 1.00 | TRPM8 (0.50) | TRPM8EPHX1TRPV1KCNA5ALDH1A1 | |
| SCHEMBL24540789 | 0.88 | TRPM8 (0.46) | TRPM8EPHX1TRPV1ALDH1A1GAA | |
| SCHEMBL2628624 | 0.86 | TRPM8 (0.67) | TRPM8EPHX1TRPV1 | |
| SCHEMBL24540605 | 0.85 | TRPM8 (0.47) | TRPM8EPHX1TRPV1KCNA5ALDH1A1 | |
| SCHEMBL24540645 | 0.84 | TRPM8 (0.47) | TRPM8EPHX1TRPV1GAAP2RX4 | |
| SCHEMBL24540501 | 0.84 | TRPM8 (0.47) | TRPM8EPHX1TRPV1KCNA5ALDH1A1 | |
| SCHEMBL4813136 | 0.82 | MC4R (0.52) | TRPM8EPHX1ALDH1A1SMN1; SMN2 | |
| SCHEMBL24540769 | 0.82 | SERPINE1 (0.48) | TRPM8EPHX1KCNA5ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083493-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2012-04-05 | — | — | US | disclosed |
| EP-2268273-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083493-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | TRPC4, TRPC3, TRPC1 | TRPM8 7/4885EPHX1 2888/4885TRPV1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.