Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24540605 | 0.88 | TRPM8 (0.47) | TRPM8EPHX1ALDH1A1HPGDP2RX4 | |
| SCHEMBL19058455 | 0.84 | TRPM8 (0.50) | TRPM8EPHX1ALDH1A1P2RX4KCNA5 | |
| SCHEMBL2628610 | 0.84 | TRPM8 (0.50) | TRPM8EPHX1ALDH1A1P2RX4KCNA5 | |
| SCHEMBL24540511 | 0.84 | TRPM8 (0.50) | TRPM8EPHX1ALDH1A1P2RX4KCNA5 | |
| SCHEMBL891394 | 0.84 | TRPM8 (0.50) | TRPM8EPHX1ALDH1A1P2RX4KCNA5 | |
| SCHEMBL24540647 | 0.83 | TRPM8 (0.46) | TRPM8EPHX1ALDH1A1HPGDP2RX4 | |
| SCHEMBL2628625 | 0.80 | TRPM8 (0.49) | TRPM8EPHX1ALDH1A1HPGDLMNA | |
| SCHEMBL24540352 | 0.79 | TRPM8 (0.46) | TRPM8EPHX1ALDH1A1HPGDP2RX4 | |
| SCHEMBL2628725 | 0.78 | P2RX7 (0.48) | TRPM8EPHX1TRPV1 | |
| SCHEMBL24540789 | 0.77 | TRPM8 (0.46) | TRPM8EPHX1ALDH1A1HPGDP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133027-A1 | SUBSTITUTED CYCLOHEXANECARBOXAMIDES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION | SANOFI (FR) | 2022-06-23 | — | — | WO | disclosed |