SCHEMBL24543296 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	KDM4E	B2RXH2	4/20	0.39

▸	TSHR	P16473	4/20	0.39

▸	SMN1; SMN2	Q16637	3/20	0.39

▸	POLB	P06746	1/20	0.39

▸	ALDH1A1	P00352	3/20	0.38

▸	KMT2A	Q03164	5/20	0.38

▸	MEN1	O00255	4/20	0.38

▸	TDP1	Q9NUW8	1/20	0.36

▸	L3MBTL1	Q9Y468	1/20	0.36

▸	GAA	P10253	2/20	0.35

▸	LMNA	P02545	2/20	0.35

▸	MAPT	P10636	2/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24543294	0.86	SLC6A3 (0.37)	ALDH1A1MAPT
SCHEMBL16534664	0.77	TDP1 (0.41)	KDM4ETSHRSMN1; SMN2POLBALDH1A1
SCHEMBL2732787	0.77	KDM4E (0.36)	KDM4ETSHRSMN1; SMN2POLBALDH1A1
SCHEMBL24542978	0.75	ALDH1A1 (0.36)	KDM4ETSHRSMN1; SMN2POLBALDH1A1
SCHEMBL29960448	0.72	MAOB (0.39)	KDM4ETSHRSMN1; SMN2POLBALDH1A1
SCHEMBL20480571	0.71	CYP1A2 (0.40)	KDM4ETSHRSMN1; SMN2POLBALDH1A1
SCHEMBL20482324	0.71	CYP1A2 (0.40)	KDM4ETSHRSMN1; SMN2POLBALDH1A1
SCHEMBL20480193	0.71	CYP1A2 (0.40)	KDM4ETSHRSMN1; SMN2POLBALDH1A1
Hydrochloric Acid SCHEMBL29960232	0.71	TSHR (0.32)	KDM4ETSHRSMN1; SMN2POLBALDH1A1
SCHEMBL29960462	0.70	TP53 (0.40)	KDM4ETSHRSMN1; SMN2POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022127827-A1	KRASG12C PROTEIN MUTATION INHIBITOR AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF	上海维申医药有限公司	2022-06-23	—	—	WO	disclosed