Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24547734 | 0.89 | SMN1; SMN2 (0.45) | CCNE1CDK2NPC1RAB9AKMT2A | |
| SCHEMBL27267989 | 0.89 | CNR1 (0.42) | CCNE1CDK2NPC1RAB9ACNR2 | |
| SCHEMBL24547740 | 0.87 | RAB9A (0.36) | NPC1RAB9AKMT2ASMN1; SMN2CNR2 | |
| SCHEMBL24468603 | 0.80 | KDM4E (0.35) | MAP4K4KMT2ASMN1; SMN2PRMT5KCNH2 | |
| SCHEMBL29650940 | 0.80 | KDM4E (0.35) | MAP4K4KMT2ASMN1; SMN2PRMT5KCNH2 | |
| SCHEMBL29138848 | 0.79 | EIF4A3 (0.37) | TRPC6PRMT5KCNH2 | |
| SCHEMBL24540932 | 0.79 | EIF4A3 (0.37) | TRPC6PRMT5KCNH2 | |
| SCHEMBL29686097 | 0.78 | KDM4E (0.32) | — | |
| SCHEMBL24468209 | 0.78 | KDM4E (0.32) | — | |
| Hydrochloric Acid SCHEMBL29106338 | 0.77 | KDM4E (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132914-A1 | PRMTS INHIBITORS | AMGEN INC. (US) | 2022-06-23 | — | — | WO | disclosed |