Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27267989 | 0.91 | CNR1 (0.42) | HPGDALDH1A1CCNCCDK8NPC1 | |
| SCHEMBL24547740 | 0.89 | RAB9A (0.36) | SMN1; SMN2HPGDALDH1A1TP53KDM4E | |
| SCHEMBL24547768 | 0.89 | NCF1 (0.36) | SMN1; SMN2NPC1RAB9ACCNE1CDK2 | |
| SCHEMBL29650940 | 0.81 | KDM4E (0.35) | SMN1; SMN2HPGDALDH1A1KDM4EALOX15 | |
| SCHEMBL24468603 | 0.81 | KDM4E (0.35) | SMN1; SMN2HPGDALDH1A1KDM4EALOX15 | |
| SCHEMBL29686097 | 0.80 | KDM4E (0.32) | KDM4E | |
| SCHEMBL24468209 | 0.80 | KDM4E (0.32) | KDM4E | |
| Hydrochloric Acid SCHEMBL29686221 | 0.79 | KDM4E (0.31) | KDM4E | |
| Hydrochloric Acid SCHEMBL29106338 | 0.79 | KDM4E (0.31) | KDM4E | |
| SCHEMBL24540849 | 0.79 | CCNE1 (0.37) | CCNCCDK8CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024118897-A1 | CANCER TREATMENTS USING A PRMT5 INHIBITOR AND A MAT2A INHIBITOR | AMGEN INC. (US) | 2024-06-06 | — | — | WO | disclosed |
| WO-2022132914-A1 | PRMTS INHIBITORS | AMGEN INC. (US) | 2022-06-23 | — | — | WO | disclosed |