SCHEMBL24548686

[N-]=[N+]=NCOC1CC(n2cc(C#CCNC(=O)COC(COc3cccc(C(=O)NCCCCCNC(=O)CCCCCNC(=O)COc4cc(S(=O)(=O)O)c5ccc6c(S(=O)(=O)O)cc(S(=O)(=O)O)c7ccc4c5c76)c3)N=[N+]=[N-])c(=O)[nH]c2=O)OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O

nearest known ligand 0.40

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	POLB	P06746	2/20	0.34

▸	POLA1	P09884	1/20	0.34

▸	POLD1	P28340	1/20	0.34

▸	P2RY2	P41231	1/20	0.31

▸	P2RY4	P51582	1/20	0.31

▸	P2RY6	Q15077	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL24548685	0.92	P2RY2 (0.35)	P2RY2P2RY4P2RY6
SCHEMBL24570761	0.89	P2RY2 (0.33)	P2RY2P2RY4P2RY6
SCHEMBL15728355	0.86	POLB (0.37)	POLBPOLA1POLD1P2RY2P2RY6
SCHEMBL17066720	0.83	POLB (0.37)	POLBPOLA1POLD1P2RY2P2RY6
SCHEMBL15799880	0.83	POLB (0.38)	POLBPOLA1POLD1P2RY2P2RY6
SCHEMBL24548655	0.82	GIGYF2 (0.38)	—
SCHEMBL17636634	0.81	POLB (0.37)	POLBPOLA1POLD1P2RY2P2RY6
SCHEMBL15799931	0.80	POLB (0.39)	POLBPOLA1POLD1P2RY2P2RY6
SCHEMBL13891877	0.80	POLB (0.35)	POLBPOLA1POLD1P2RY2P2RY6
SCHEMBL17227503	0.80	POLB (0.35)	POLBPOLA1POLD1P2RY2P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2022136402-A1	METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING	ILLUMINA CAMBRIDGE LIMITED (GB)	2022-06-30	—	—	WO	disclosed
US-20220195518-A1	METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING	ILLUMINA CAMBRIDGE LIMITED (GB)	2022-06-23	—	—	US	disclosed