Biphenyl

Biphenyl

SCHEMBL2455099

Cc1cccc(C)c1C=O.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.48
TSHR P16473 2/20 0.48
LMNA P02545 2/20 0.42
BRD4 O60885 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
ACHE P22303 1/20 0.39
RAB9A P51151 1/20 0.39
RPA1 P27694 1/20 0.39
MCL1 Q07820 1/20 0.39
CYP2A6 P11509 1/20 0.39
NTSR1 P30989 1/20 0.38
GPR55 Q9Y2T6 1/20 0.38
RET P07949 1/20 0.38
TNKS2 Q9H2K2 1/20 0.38
ERN1 O75460 1/20 0.38
TP53 P04637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL66979 0.88 ALDH1A1 (0.52) ALDH1A1TSHRLMNANPSR1KDM4E
SCHEMBL28641344 0.85 ALDH1A1 (0.50) ALDH1A1TSHRLMNANPSR1KDM4E
SCHEMBL309416 0.85 KDM4E (0.45) ALDH1A1TSHRLMNANPSR1KDM4E
SCHEMBL30404870 0.85 KDM4E (0.45) ALDH1A1TSHRLMNANPSR1KDM4E
Phenol SCHEMBL11759995 0.83 CA12 (0.46) ALDH1A1TSHRLMNANPSR1KDM4E
Methylene Chloride SCHEMBL27759956 0.79 ALDH1A1 (0.46) ALDH1A1TSHRLMNANPSR1KDM4E
SCHEMBL1830917 0.76 ALDH1A1 (0.46) ALDH1A1TSHRLMNABRD4NPSR1
SCHEMBL16704711 0.76 ERN1 (0.47) ALDH1A1TSHRLMNANPSR1ERN1
SCHEMBL1707832 0.75 ESR2 (0.40) ALDH1A1TSHRLMNABRD4NPSR1
SCHEMBL548632 0.74 ALDH1A1 (0.62) ALDH1A1TSHRLMNANPSR1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9176257-B2 Conjugated aromatic compound, optical material, and optical element CANON KABUSHIKI KAISHA (JP) 2015-11-03 US disclosed
US-20120330052-A1 CONJUGATED AROMATIC COMPOUND, OPTICAL MATERIAL, AND OPTICAL ELEMENT CANON KABUSHIKI KAISHA (JP) 2012-12-27 US disclosed
WO-2011118541-A1 CONJUGATED AROMATIC COMPOUND, OPTICAL MATERIAL, AND OPTICAL ELEMENT CANON KABUSHIKI KAISHA (JP) 2011-09-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120330052-A1 CONJUGATED AROMATIC COMPOUND, OPTICAL MATERIAL, AND OPTICAL ELEMENT AHR, AXIN2, NR2E3 ALDH1A1 605/4885TSHR 4020/4885LMNA 2747/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.