Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 9/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | GFER | P55789 | 2/20 | 0.57 |
| ▸ | CHIA | Q9BZP6 | 8/20 | 0.46 |
| ▸ | CHIT1 | Q13231 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9793471 | 0.98 | GAA (0.67) | GAAMAPTALDH1A1GFERCHIA | |
| SCHEMBL20628967 | 0.82 | CHIT1 (0.60) | GAAMAPTALDH1A1GFERCHIA | |
| SCHEMBL9793417 | 0.82 | GAA (0.62) | GAAMAPTALDH1A1GFERCHIA | |
| SCHEMBL1994355 | 0.82 | GAA (1.00) | GAAMAPTALDH1A1GFERCHIA | |
| SCHEMBL31387185 | 0.76 | GAA (0.56) | GAAMAPTALDH1A1GFERCHIA | |
| SCHEMBL31214493 | 0.75 | GAA (0.63) | GAAMAPTALDH1A1GFERCHIA | |
| SCHEMBL25037188 | 0.74 | GAA (0.53) | GAAMAPTALDH1A1GFERCHIA | |
| SCHEMBL25036705 | 0.71 | GAA (0.54) | GAAMAPTALDH1A1GFERCHIA | |
| SCHEMBL31214557 | 0.70 | GAA (0.57) | GAAMAPTALDH1A1GFERCHIA | |
| SCHEMBL18610008 | 0.69 | CHIT1 (0.60) | GAAMAPTCHIACHIT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |