Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.55 |
| ▸ | MITF | O75030 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MYC | P01106 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24559333 | 0.93 | MAPT (0.55) | MAPTNCOA3MITFRAB9ACISD1 | |
| SCHEMBL24559308 | 0.92 | ADORA2B (0.53) | MAPTKMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL24559280 | 0.85 | PTPN12 (0.52) | MAPTKMT2AKDM4EALDH1A1AKR1B1 | |
| SCHEMBL24559408 | 0.82 | ADORA2B (0.50) | MAPTKMT2AHTTALDH1A1ADORA2B | |
| SCHEMBL24559155 | 0.78 | LMNA (0.57) | MAPTRAB9AHTTALDH1A1ADORA2B | |
| SCHEMBL24559443 | 0.77 | MAPT (0.54) | MAPTNCOA3MITFRAB9ACISD1 | |
| SCHEMBL12008740 | 0.76 | MYC (0.83) | MAPTNCOA3MITFRAB9ACISD1 | |
| SCHEMBL12008711 | 0.75 | CISD1 (0.81) | MAPTNCOA3MITFRAB9ACISD1 | |
| SCHEMBL24559158 | 0.75 | LMNA (0.64) | MAPTHTTALDH1A1ADORA2BSMN1; SMN2 | |
| SCHEMBL12008748 | 0.74 | CISD1 (0.79) | MAPTNCOA3MITFRAB9ACISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220202821-A1 | SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220202821-A1 | SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF | PARG, PARP15, PLG | MAPT 4393/4885NCOA3 2039/4885MITF 3801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.