Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | UBE2N | P61088 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24559334 | 0.82 | MAPT (0.55) | ADORA2BRXFP1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL24559308 | 0.77 | ADORA2B (0.53) | ADORA2BRXFP1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL24559333 | 0.75 | MAPT (0.55) | LMNAHTTKMT2AALDH1A1MAPT | |
| SCHEMBL24559155 | 0.73 | LMNA (0.57) | ADORA2BRXFP1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL17750785 | 0.72 | LMNA (0.89) | ADORA2BRXFP1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL24559158 | 0.72 | LMNA (0.64) | ADORA2BRXFP1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL24559245 | 0.71 | LMNA (0.60) | ADORA2BRXFP1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL29256880 | 0.71 | ADORA2B (0.74) | ADORA2BRXFP1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL24559303 | 0.71 | LMNA (0.59) | ADORA2BRXFP1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL9296212 | 0.70 | ADORA2B (0.76) | ADORA2BRXFP1SMN1; SMN2LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220202821-A1 | SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220202821-A1 | SMALL MOLECULE PARG INHIBITORS AND METHODS OF USE THEREOF | PARG, PARP15, PLG | ADORA2B 2231/4885RXFP1 2773/4885SMN1; SMN2 4491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.