Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 9/20 | 0.39 |
| ▸ | MET | P08581 | 10/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715654 | 0.89 | MET (0.38) | FYNMETCAMK2D | |
| SCHEMBL2532173 | 0.87 | FYN (0.43) | FYNMETCAMK2D | |
| SCHEMBL2452496 | 0.84 | MET (0.40) | FYNMET | |
| SCHEMBL14715539 | 0.82 | MET (0.39) | FYNMET | |
| SCHEMBL2456961 | 0.82 | MET (0.38) | FYNMET | |
| SCHEMBL12224223 | 0.80 | MET (0.43) | FYNMET | |
| SCHEMBL2452860 | 0.79 | MET (0.40) | FYNMET | |
| SCHEMBL14715546 | 0.79 | MET (0.41) | FYNMET | |
| SCHEMBL12245542 | 0.79 | FYN (0.49) | FYNCAMK2D | |
| SCHEMBL12224229 | 0.78 | SMN1; SMN2 (0.48) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367827-B1 | 3-(3-PYRIMIDINE-2-YL-BENZYL)-[1,2,4]TRIAZOLO [4,3-b]PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-02-27 | — | — | EP | claimed |
| EP-2367827-B1 | 3-(3-PYRIMIDINE-2-YL-BENZYL)-[1,2,4]TRIAZOLO [4,3-b]PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-02-27 | — | — | EP | disclosed |
| EP-2367827-A1 | 3-(3-PYRIMIDINE-2-YL-BENZYL)-Ý1,2,4¨TRIAZOLO Ý4,3-B¨PYRIDAZINE DERIVATIVES | Merck Patent GmbH (DE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010072301-A1 | 3-(3-PYRIMIDINE-2-YL-BENZYL)-[1,2,4] TRIAZOLO [4,3-B] PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-07-01 | — | — | WO | disclosed |