Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29872986 | 0.89 | CNR2 (0.45) | CNR1CNR2PDE1BALDH1A1LMNA | |
| SCHEMBL23069193 | 0.86 | CNR1 (0.44) | CNR1CNR2PDE1BALDH1A1LMNA | |
| SCHEMBL1593023 | 0.85 | CNR1 (0.47) | CNR1CNR2PDE1BALDH1A1LMNA | |
| SCHEMBL28431878 | 0.85 | CNR1 (0.47) | CNR1CNR2PDE1BALDH1A1LMNA | |
| SCHEMBL1592906 | 0.85 | PDE1B (0.55) | CNR1CNR2PDE1BALDH1A1LMNA | |
| SCHEMBL28431943 | 0.83 | PDE1B (0.49) | CNR1CNR2PDE1BALDH1A1LMNA | |
| SCHEMBL28425625 | 0.82 | PDE1B (0.48) | CNR1CNR2PDE1BALDH1A1SMN1; SMN2 | |
| SCHEMBL1592875 | 0.81 | NR3C1 (0.45) | CNR1CNR2ALDH1A1LMNAMAPT | |
| SCHEMBL28428236 | 0.81 | PDE1B (0.47) | CNR1CNR2PDE1BALDH1A1LMNA | |
| SCHEMBL1594020 | 0.78 | CNR1 (0.46) | CNR1CNR2PDE1BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |