Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 7/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29762969 | 1.00 | PDE1A (0.32) | PDE1APDE1BPDE1CPIK3CAMAP3K12 | |
| SCHEMBL24567219 | 0.93 | — | — | |
| SCHEMBL24567227 | 0.77 | PIK3CA (0.40) | PDE1APDE1BPDE1CPIK3CAMAP3K12 | |
| SCHEMBL24007638 | 0.75 | P2RX7 (0.32) | — | |
| SCHEMBL24567226 | 0.73 | TMIGD3 (0.39) | PIK3CAMAP3K12CNR2 | |
| SCHEMBL24567211 | 0.73 | TMIGD3 (0.39) | PIK3CAMAP3K12CNR2 | |
| SCHEMBL24007900 | 0.71 | KDM4E (0.33) | — | |
| SCHEMBL24007649 | 0.71 | PDE1A (0.30) | PDE1APDE1BPDE1C | |
| SCHEMBL24567216 | 0.70 | PIK3CA (0.34) | PIK3CAMAP3K12 | |
| SCHEMBL24007985 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267574-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |