Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 8/20 | 0.33 |
| ▸ | PDE8B | O95263 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 6/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.31 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24567227 | 0.92 | PIK3CA (0.40) | PIK3CAMAP3K12RETPIK3CDPIK3CB | |
| SCHEMBL24567219 | 0.78 | — | — | |
| SCHEMBL24567218 | 0.75 | TMIGD3 (0.37) | KDM4CPKM | |
| SCHEMBL24007906 | 0.72 | PIK3CA (0.33) | PIK3CAPDE8B | |
| SCHEMBL29762969 | 0.70 | PDE1A (0.32) | PIK3CAMAP3K12 | |
| SCHEMBL24566675 | 0.70 | PDE1A (0.32) | PIK3CAMAP3K12 | |
| SCHEMBL20689321 | 0.68 | TYK2 (0.41) | PIK3CAKDM4CLMNA | |
| SCHEMBL20689467 | 0.68 | TYK2 (0.40) | PIK3CATP53 | |
| SCHEMBL24007635 | 0.67 | MPO (0.36) | RETNPC1LMNATP53PKM | |
| SCHEMBL18692960 | 0.66 | KCNH2 (0.35) | PIK3CAMAP3K12KDM4CPIK3CDPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |