Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 5/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24567211 | 1.00 | TMIGD3 (0.39) | TMIGD3ADORA1PDE10AF2GAA | |
| SCHEMBL24567218 | 0.94 | TMIGD3 (0.37) | TMIGD3ADORA1PDE10AF2GAA | |
| SCHEMBL24567228 | 0.86 | KDM4C (0.36) | GAACNR2IRAK4FPR1 | |
| SCHEMBL24567209 | 0.86 | KDM4C (0.36) | GAACNR2IRAK4FPR1 | |
| SCHEMBL24007637 | 0.78 | ADORA1 (0.46) | TMIGD3ADORA1GAACYP3A4CYP2C19 | |
| SCHEMBL24007919 | 0.75 | TMIGD3 (0.43) | TMIGD3ADORA1PDE10AGAACYP3A4 | |
| SCHEMBL24567227 | 0.74 | PIK3CA (0.40) | TGFBR1PIK3CAMAP3K12 | |
| SCHEMBL24566675 | 0.73 | PDE1A (0.32) | PIK3CACNR2MAP3K12 | |
| SCHEMBL29762969 | 0.73 | PDE1A (0.32) | PIK3CACNR2MAP3K12 | |
| SCHEMBL24008156 | 0.72 | TMIGD3 (0.35) | TMIGD3ADORA1F2GAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |