Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24567228 | 1.00 | KDM4C (0.36) | KDM4CGAAKDM4EMITFALDH1A1 | |
| SCHEMBL24567211 | 0.86 | TMIGD3 (0.39) | GAAIRAK4CNR2FPR1 | |
| SCHEMBL24567226 | 0.86 | TMIGD3 (0.39) | GAAIRAK4CNR2FPR1 | |
| SCHEMBL24567218 | 0.80 | TMIGD3 (0.37) | KDM4CGAAKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL24007634 | 0.73 | KDM4E (0.44) | KDM4EMITFALDH1A1HPGDKLF5 | |
| SCHEMBL24815180 | 0.70 | KDM4E (0.35) | GAAKDM4EMITFALDH1A1HPGD | |
| SCHEMBL24007902 | 0.70 | KDM4E (0.41) | GAAKDM4EMITFALDH1A1HPGD | |
| SCHEMBL24567215 | 0.68 | KDM4E (0.35) | GAAKDM4EMITFALDH1A1HPGD | |
| SCHEMBL24007637 | 0.64 | ADORA1 (0.46) | GAAKDM4EMITFALDH1A1HPGD | |
| SCHEMBL31725450 | 0.62 | PDE1A (0.42) | KDM4CPDE1APDE1BPDE1CCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |