Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 4/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24567211 | 0.94 | TMIGD3 (0.39) | TMIGD3ADORA1F2CNR2PDE10A | |
| SCHEMBL24567226 | 0.94 | TMIGD3 (0.39) | TMIGD3ADORA1F2CNR2PDE10A | |
| SCHEMBL24567228 | 0.80 | KDM4C (0.36) | KDM4CCNR2GAAKCNJ6KCNJ5 | |
| SCHEMBL24567209 | 0.80 | KDM4C (0.36) | KDM4CCNR2GAAKCNJ6KCNJ5 | |
| SCHEMBL24007637 | 0.76 | ADORA1 (0.46) | TMIGD3ADORA1GAABRPF1CYP3A4 | |
| SCHEMBL24567216 | 0.75 | PIK3CA (0.34) | KDM4CPKM | |
| SCHEMBL24567219 | 0.74 | — | — | |
| SCHEMBL24007919 | 0.73 | TMIGD3 (0.43) | TMIGD3ADORA1PDE10AGAABRPF1 | |
| SCHEMBL24567217 | 0.72 | TMIGD3 (0.37) | TMIGD3ADORA1F2GAABRPF1 | |
| SCHEMBL24567227 | 0.67 | PIK3CA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |