SCHEMBL24567503

SCHEMBL24567503

CC(C)[C@@H](C)NC(=O)OCC(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
LMNA P02545 2/20 0.41
CYP3A4 P08684 1/20 0.41
NFKB1 P19838 1/20 0.41
ADRA1A P35348 1/20 0.41
RAB9A P51151 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CTSK P43235 2/20 0.39
KMT2A Q03164 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA7 P43166 1/20 0.37
SMN1; SMN2 Q16637 3/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.34
CYP2D6 P10635 1/20 0.33
HRH3 Q9Y5N1 2/20 0.32
CTSS P25774 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24427421 0.84 HRH3 (0.43) TSHRLMNACYP3A4NFKB1ADRA1A
SCHEMBL12890775 0.83 TSHR (0.56) TSHRLMNACYP3A4NFKB1ADRA1A
SCHEMBL22649551 0.78 TYR (0.41) TSHRLMNACYP3A4NFKB1ADRA1A
SCHEMBL13127979 0.78 TSHR (0.41) TSHRLMNACYP3A4NFKB1ADRA1A
SCHEMBL68958 0.77 TSHR (0.43) TSHRLMNACYP3A4NFKB1ADRA1A
SCHEMBL13035444 0.77 SMN1; SMN2 (0.44) LMNASMN1; SMN2GAAL3MBTL1HTT
SCHEMBL13921054 0.77 CTSK (0.47) TSHRLMNACYP3A4NFKB1ADRA1A
SCHEMBL13921045 0.77 CTSK (0.47) TSHRLMNACYP3A4NFKB1ADRA1A
SCHEMBL24568601 0.76 TSHR (0.39) TSHRLMNACYP3A4NFKB1ADRA1A
SCHEMBL13195188 0.75 L3MBTL1 (0.36) TSHRLMNACYP3A4NFKB1ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022140428-A2 INHIBITORS OF PEPTIDYLARGININE DEIMINASES GILEAD SCIENCES, INC. (US) 2022-06-30 WO disclosed