Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18793674 | 1.00 | POLB (0.45) | POLBTRPA1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL19171934 | 0.82 | NPC1 (0.42) | POLBTRPA1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5019737 | 0.80 | POLB (0.48) | POLBTRPA1NPC1RAB9AMEN1 | |
| SCHEMBL2820334 | 0.79 | TAS1R3 (0.46) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL24568367 | 0.79 | TAS1R3 (0.38) | POLBTRPA1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL13135688 | 0.76 | TRPA1 (0.53) | POLBTRPA1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9343215 | 0.76 | TRPA1 (0.53) | POLBTRPA1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6488388 | 0.74 | POLB (0.43) | POLBTRPA1NPC1RAB9AMEN1 | |
| SCHEMBL6488391 | 0.74 | POLB (0.43) | POLBTRPA1NPC1RAB9AMEN1 | |
| SCHEMBL13127924 | 0.74 | POLB (0.43) | POLBTRPA1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140428-A2 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2022-06-30 | — | — | WO | disclosed |