Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.53 |
| ▸ | PTGES | O14684 | 4/20 | 0.52 |
| ▸ | ACACB | O00763 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305512 | 0.87 | LMNA (0.58) | LMNARIPK1NAMPTCHRNB2CHRNA4 | |
| SCHEMBL7305521 | 0.87 | LMNA (0.58) | LMNARIPK1NAMPTCHRNB2CHRNA4 | |
| SCHEMBL7311229 | 0.84 | LMNA (0.53) | LMNARIPK1NAMPTCHRNB2CHRNA4 | |
| SCHEMBL7311226 | 0.84 | LMNA (0.53) | LMNARIPK1NAMPTCHRNB2CHRNA4 | |
| SCHEMBL7670730 | 0.83 | SMN1; SMN2 (0.58) | LMNARIPK1CHRNB2CHRNA4PTGES | |
| SCHEMBL28336676 | 0.82 | RIPK1 (0.52) | LMNARIPK1NAMPTCHRNB2CHRNA4 | |
| SCHEMBL12890606 | 0.82 | NPC1 (0.61) | PTGESKMT2AHPGD | |
| SCHEMBL13266974 | 0.81 | RIPK1 (0.60) | LMNARIPK1NAMPTCHRNB2CHRNA4 | |
| SCHEMBL14540710 | 0.81 | LMNA (0.72) | LMNARIPK1NAMPTCHRNB2CHRNA4 | |
| SCHEMBL13244885 | 0.80 | RIPK1 (0.63) | LMNARIPK1NAMPTCHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140428-A2 | INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2022-06-30 | — | — | WO | disclosed |