Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21203873 | 0.77 | HDAC6 (0.37) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL21880331 | 0.77 | HDAC6 (0.37) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL22154645 | 0.76 | CA14 (0.36) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL15370926 | 0.76 | CA14 (0.39) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL5742200 | 0.76 | CA14 (0.39) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL24570234 | 0.75 | SQLE (0.36) | HDAC6 | |
| SCHEMBL9535145 | 0.75 | HDAC6 (0.35) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL1193477 | 0.75 | HDAC6 (0.35) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL9537778 | 0.75 | CTSK (0.34) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL2836031 | 0.74 | HDAC6 (0.38) | HDAC6HDAC1HDAC2CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |