Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6637022 | 0.84 | KDM4E (0.45) | KDM4EALDH1A1MAPTALOX15CMA1 | |
| SCHEMBL27090145 | 0.81 | NPBWR1 (0.44) | KDM4EALDH1A1MAPTALOX15CMA1 | |
| SCHEMBL30525417 | 0.79 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPTALOX15CMA1 | |
| SCHEMBL27090143 | 0.79 | CNR1 (0.43) | KDM4EALDH1A1MAPTALOX15CMA1 | |
| SCHEMBL16014865 | 0.79 | NR1H3 (0.44) | KDM4EALDH1A1MAPTCYP1A2CYP3A4 | |
| SCHEMBL16014514 | 0.79 | MET (0.44) | KDM4EALDH1A1MAPTALOX15CMA1 | |
| SCHEMBL15538235 | 0.78 | CMA1 (0.43) | KDM4EALDH1A1MAPTALOX15CMA1 | |
| SCHEMBL24569972 | 0.77 | PDE8B (0.42) | ALDH1A1MAPTALOX15CMA1NPBWR1 | |
| SCHEMBL24569408 | 0.77 | CNR1 (0.44) | KDM4EALDH1A1MAPTALOX15CMA1 | |
| SCHEMBL15556088 | 0.77 | MAPT (0.40) | KDM4EALDH1A1MAPTALOX15CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710450-A | Pyrrolo [3,2-b ] pyridine derivatives for the treatment of cGAS-related disorders | 诺华股份有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-116635382-A | Indole derivatives useful for treating cGAS-related disorders | 诺华股份有限公司 | 2023-08-22 | — | — | CN | disclosed |
| WO-2022137082-A1 | PYRROLO[3,2-B]PYRIDINE DERIVATIVES USEFUL IN TREATING CONDITIONS ASSOCIATED WITH CGAS | NOVARTIS AG (CH) | 2022-06-30 | — | — | WO | disclosed |
| WO-2022137085-A1 | INDOLE DERIVATIVES USEFUL IN TREATING CONDITIONS ASSOCIATED WITH CGAS | NOVARTIS AG (CH) | 2022-06-30 | — | — | WO | disclosed |