Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | STAT3 | P40763 | 4/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25957468 | 0.80 | SIGMAR1 (0.37) | SIGMAR1STAT3APPALDH1A1MEN1 | |
| SCHEMBL13879940 | 0.80 | SIGMAR1 (0.37) | SIGMAR1STAT3APPALDH1A1MEN1 | |
| SCHEMBL8000704 | 0.78 | HPGD (0.37) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL12190764 | 0.73 | APP (0.37) | SIGMAR1STAT3APPALDH1A1MEN1 | |
| SCHEMBL29661787 | 0.72 | APP (0.46) | SIGMAR1STAT3APPALDH1A1MEN1 | |
| SCHEMBL12301896 | 0.72 | APP (0.46) | SIGMAR1STAT3APPALDH1A1MEN1 | |
| SCHEMBL12740474 | 0.70 | POLB (0.43) | SIGMAR1APPALDH1A1MEN1KMT2A | |
| SCHEMBL4611466 | 0.70 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL18463381 | 0.69 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL956895 | 0.68 | PRKCI (0.50) | SIGMAR1ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |