Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | STAT3 | P40763 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.34 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25957468 | 0.80 | SIGMAR1 (0.37) | SIGMAR1STAT3ALDH1A1MAPTKMT2A | |
| SCHEMBL24569887 | 0.80 | SIGMAR1 (0.37) | SIGMAR1STAT3ALDH1A1MAPTKMT2A | |
| SCHEMBL9706128 | 0.78 | HPGD (0.41) | ALDH1A1MAPTKMT2AMEN1KDM4E | |
| SCHEMBL22158000 | 0.77 | AKR1C3 (0.42) | ALDH1A1MAPTKMT2AMEN1HTT | |
| SCHEMBL18474287 | 0.76 | PRKCI (0.38) | SIGMAR1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL18077360 | 0.76 | KDM4E (0.49) | STAT3ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL13689913 | 0.76 | HTT (0.36) | ALDH1A1MAPTKMT2AMEN1POLB | |
| SCHEMBL12190764 | 0.73 | APP (0.37) | SIGMAR1STAT3ALDH1A1MAPTKMT2A | |
| SCHEMBL10314645 | 0.73 | ALDH1A1 (0.36) | ALDH1A1KDM4ESMN1; SMN2RAB9ATSHR | |
| SCHEMBL14089586 | 0.72 | SIGMAR1 (0.36) | SIGMAR1ALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020240492-A1 | 1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2020-12-03 | — | — | WO | disclosed |
| US-7524873-B2 | Substituted N-phenylmethyl ethanamines; N-((6-(methyloxy)-4'-(trifluoromethyl)-1,1'-biphenyl-3-yl)methyl)-1-(1-naphthalenyl)ethanamine; parathyroid hormone inhibitors; antisecretory agents; osteoporosis | AMGEN INC. (US) | 2009-04-28 | — | — | US | disclosed |