Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 12/20 | 0.41 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2429495 | 0.90 | ENPP1 (0.43) | ENPP1CCR2ALKBH3PDE1BCCR5 | |
| SCHEMBL2455657 | 0.86 | ENPP1 (0.50) | ENPP1CCR2ALKBH3PDE1BCCR5 | |
| SCHEMBL2459450 | 0.86 | ENPP1 (0.47) | ENPP1CCR2ALKBH3PDE1BCCR5 | |
| SCHEMBL2462543 | 0.83 | ENPP1 (0.45) | ENPP1CCR2ALKBH3PDE1BCCR5 | |
| SCHEMBL2461260 | 0.83 | CCR2 (0.48) | ENPP1CCR2ALKBH3PDE1BCCR5 | |
| SCHEMBL2458532 | 0.83 | ENPP1 (0.45) | ENPP1CCR2ALKBH3PDE1BCCR5 | |
| SCHEMBL2457593 | 0.82 | ENPP1 (0.43) | ENPP1CCR2ALKBH3PDE1BCCR5 | |
| SCHEMBL2424473 | 0.82 | NR3C1 (0.48) | ENPP1CCR2ALKBH3PDE1BCCR5 | |
| SCHEMBL2462884 | 0.82 | ENPP1 (0.44) | ENPP1CCR2ALKBH3PDE1BCCR5 | |
| SCHEMBL2458512 | 0.81 | NR3C1 (0.51) | ENPP1CCR2ALKBH3PDE1BNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |